原爆被爆後の長期にわたる甲状腺がんリスク(文献情報)

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2012年09月03日(Mon) 09:10 by drharasho

気になる文献情報です。

Long-term trend of thyroid cancer risk among Japanese
atomic-bomb survivors: 60 years after exposure

Thyroid cancer risk following exposure to ionizing radiation in childhood
and adolescence is a topic of public concern. To characterize the long-term
temporal trend and age-at-exposure variation in the radiation-induced
risk of thyroid cancer, we analyzed thyroid cancer incidence data for
the period from 1958 through 2005 among 105,401 members of the Life Span
Study cohort of Japanese atomic-bomb survivors. During the follow-up period, 
371 thyroid cancer cases (excluding those with microcarcinoma with
a diameter <10 mm) were identified as a first primary among the eligible
subjects. Using a linear dose–response model, the excess relative risk
of thyroid cancer at 1 Gy of radiation exposure was estimated as 1.28 (95%
confidence interval: 0.59–2.70) at age 60 after acute exposure at age 10. 
The risk decreased sharply with increasing age-atexposure and there was
little evidence of increased thyroid cancer rates for those exposed after
age 20. About 36% of the thyroid cancer cases among those exposed
before age 20 were estimated to be attributable to radiation exposure.
While the magnitude of the excess risk has decreased with increasing
attained age or time since exposure, the excess thyroid cancer risk
associated with childhood exposure has persisted for >50 years 
after exposure.

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